Paul Saint-Amour works on nineteenth- and twentieth-century British literature and has special interests in the novel, law, trauma, visual culture, sound studies, and the environmental humanities. He received his B.A. from Yale and his Ph.D. from Stanford and has been a fellow of the Stanford Humanities Center, the American Council of Learned Societies, the Center for the Humanities at Cornell, the Howard Foundation, and the National Humanities Center. Saint-Amour's The Copywrights: Intellectual Property and the Literary Imagination (Cornell UP, 2003) won the MLA Prize for a First Book. His articles have appeared in journals such as Comparative Literature Studies, Critical Inquiry, Diacritics, ELH, Modernism/modernity, Nineteenth-Century Literature, Novel, PMLA, Post 45, Public Books, Theory, Culture, and Society, and Representations, whose special “Counterfactuals” issue he co-edited with Catherine Gallagher and Mark Maslan. With Robert Spoo and Joseph Jenkins he co-edited a special "Futures of Fair Use" issue of Law and Literature. In 2018 he edited a special issue of Modernism/modernity on weak theory.

In 2012-2013 Saint-Amour served as president of the Modernist Studies Association. He is currently a trustee of the International James Joyce Foundation (IJJF). A panel he chaired for the IJJF produced a detailed FAQ on the copyright status of Joyce's work and the general parameters of scholarly fair use. He also sits on the supervising committee of the English Institute and the faculty editorial board of the University of Pennsylvania Press.

Saint-Amour co-edits, with Jessica Berman, the Modernist Latitudes book series at Columbia UP. He edited the volume Modernism and Copyright (2011) for Oxford UP's Modernist Literature and Culture series. His most recent book, Tense Future: Modernism, Total War, Encyclopedic Form (Oxford UP, 2015), won the Modernist Studies Association Book Prize and the MLA's first annual Matei Calinescu Prize. Saint-Amour has been named a 2022 Fellow of the John Simon Guggenheim Memorial Foundation.