Kalyan Nadiminti works on twentieth and twenty-first century global Anglophone literatures, with a particular focus on South Asian Anglophone, transnational Muslim, and African diasporic literatures. He is currently an Assistant Professor of English and Mellon Faculty Fellow 2018-19 at Gettysburg College. where he is working on a scholarly monograph, Critical Fatalism: Race, Labor, and Neoliberalism in Global Anglophone Literature, which brings together transnational and diasporic writers to examine the relationship of the minoritized subject to the American ideal of white-collar work. From Jhumpa Lahiri to Mohsin Hamid to Chimamanda Ngozi Adichie, "Critical Fatalism" reads raced, gendered, and migrant subjects that query the ideology of American professionalism by mixing anti-work and anti-imperial feeling.

Kalyan's second project, Provincializing 9/11: The Geopolitics of Terror in Global Anglophone Literature and Culture, contends that global South writers construct literary genealogies of terror to interrogate the mythic status of 9/11 as a foundational event in global histories of terrorism in genres ranging from memoirs, poetry, and novels. At the invitation of the POLIS Project, he presented a portion of his work on Guantánamo literature. where he was also in conversation with former Guantánamo detainee and author Mohamedou Ould Slahi and his editor Larry Siems. 

Kalyan's work has been published in journals such as NOVEL: A Forum on Fiction, Journal of Asian American Studies, Textual Practice, South Asia Review, and Twentieth-Century Literature. He has taught courses on race, labor, and global literatures at Haverford's History department, Penn's English department, the Asian American Studies Program, and Michigan State University.